MYELIN LESIONS IN THE RABBIT EYE MODEL AS A BYSTANDER EFFECT OF HERPES-SIMPLEX AND VISNA VIRUS SENSITIZATION

被引：15

作者：

KRISTENSSON, K ^{[1
]}

THORMAR, H ^{[1
]}

WISNIEWSKI, HM ^{[1
]}

机构：

[1] LINKOPING UNIV,DEPT PATHOL 2,S-58185 LINKOPING,SWEDEN

来源：

ACTA NEUROPATHOLOGICA | 1979年 / 48卷 / 03期

关键词：

Demyelination; Herpes simplex virus; Visna virus;

D O I：

10.1007/BF00690522

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Rabbits were immunized with herpes simplex and visna virus in complete Freund's adjuvant. Uv-inactivated herpes virus and the purified visna virus protein p 25 injected intraocularly into these rabbits elicited a moderate inflammatory cell infiltration in the epiretinal myelinated nerve fiber bundles accompanied by signs of demyelination. It is therefore apparent that also viral antigen can induce myelin lesions as a socalled bystander effect" of a cell-mediated immune response (bystander demyelination). © 1979 Springer-Verlag."

引用

页码：215 / 217

页数：3

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