GERM-LINE AND SOMATIC P53 GENE-MUTATIONS IN MULTIFOCAL OSTEOGENIC-SARCOMA

被引:71
作者
IAVARONE, A
MATTHAY, KK
STEINKIRCHNER, TM
ISRAEL, MA
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT PEDIAT,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT SURG PATHOL,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,BRAIN TUMOR RES CTR,PREUSS LAB,SAN FRANCISCO,CA 94143
关键词
MULTIPLE TUMORS; P53; CANCER PREDISPOSITION; TUMOR SUPPRESSOR GENES;
D O I
10.1073/pnas.89.9.4207
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Multifocal osteogenic sarcoma patients without familial histories of increased tumor predisposition were examined for mutations in the highly conserved regions of the p53 gene. p53 point mutations were found in tumor DNA from each of the four patients we examined. A germ-line p53 mutation was detected in one of these patients, and a further rearrangement of the residual wild-type allele was detected in tumor tissue. p53 germ-line mutations can contribute to the enhanced predisposition to tumor development manifest in patients with multifocal osteosarcoma.
引用
收藏
页码:4207 / 4209
页数:3
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