KINETIC RESOLUTION OF 3-T-BUTYL AND 3-PHENYLCYCLOBUTYLIDENETHANOLS THROUGH LIPASE-CATALYZED ACYLATION WITH SUCCINIC ANHYDRIDE

被引：19

作者：

FIAUD, JC

GIL, R

LEGROS, JY

ARIBIZOUIOUECHE, L

KONIG, WA

机构：

[1] UNIV ANNABA, DEPT CHIM ORGAN, ANNABA 23000, ALGERIA

[2] UNIV HAMBURG, INST ORGAN CHEM, W-2000 HAMBURG 13, GERMANY

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 46期

关键词：

LIPASE-CATALYZED RESOLUTION; AXIALLY CHIRAL ALLYLIC ALCOHOLS; SUCCINIC ANHYDRIDE;

D O I：

10.1016/S0040-4039(00)60908-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically enriched (3-t-butyl) and (3-phenylcyclobutylidene)ethanols were readily obtained through kinetic resolution of the racemates by lipase-catalyzed acylation with succinic anhydride; the procedure is of practical use and does not require a chromatographic separation.

引用

收藏

页码：6967 / 6970

页数：4

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