CHARACTERIZATION OF A DNA-SEQUENCE FAMILY IN THE PRADER-WILLI ANGELMAN SYNDROME CHROMOSOME REGION IN 15Q11-Q13

被引：5

作者：

DITTRICH, B ^{[1
]}

KNOBLAUCH, H ^{[1
]}

BUITING, K ^{[1
]}

HORSTHEMKE, B ^{[1
]}

机构：

[1] UNIV ESSEN GESAMTHSCH KLINIKUM,INST HUMANGENET,HUFELANDSTR 55,W-4300 ESSEN 1,GERMANY

来源：

GENOMICS | 1993年 / 16卷 / 01期

关键词：

D O I：

10.1006/geno.1993.1175

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

IR4-3R (D15S11) is an anonymous DNA sequence from human chromosome 15. Using YAC cloning and restriction enzyme analysis, we have found that IR4-3R detects five related DNA sequences, which are spread over 700 kb within the Prader-Willi/Angelman syndrome chromosome region in 15q11-q13. The RsaI and StyI polymorphisms, which were described previously, are associated with the most proximal copy of IR4-3R and are in strong linkage disequilibrium. IR4-3R represents the third DNA sequence family that has been identified in 15q11-q13. © 1993 Academic Press. All rights reserved.

引用

页码：269 / 271

页数：3

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