PD135158, A CCK-B ANTAGONIST, REDUCES STATE, BUT NOT TRAIT ANXIETY IN MICE

被引：38

作者：

BELZUNG, C ^{[1
]}

PINEAU, N ^{[1
]}

BEUZEN, A ^{[1
]}

MISSLIN, R ^{[1
]}

机构：

[1] LAB PSYCHOPHYSIOL,F-67000 STRASBOURG,FRANCE

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 49卷 / 02期

关键词：

MICE; LIGHT/DARK CHOICE TEST; NEOPHOBIA; BALB/C; FREE EXPLORATION TEST; PD135158; CCK-B ANTAGONISTS; STATE ANXIETY; TRAIT ANXIETY;

D O I：

10.1016/0091-3057(94)90445-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

It has recently been proposed that Balb/c neophobic responses in a free exploratory paradigm are related to ''trait'' anxiety, while the behavior of mice in the light/dark choice test paradigm is related to ''state'' anxiety. The purpose of this study was to assess the action of the CCK-B receptor antagonist PD135158 in both models. Results show that PD135158 was effective in the light/dark choice test but not on the Balb/c neophobic reactions in the free exploratory situation. It is suggested that PD135158 is specially effective in state anxiety induced by fear provoking situations.

引用

页码：433 / 436

页数：4

共 16 条

[1] ANXIOGENIC EFFECTS OF METHYL-BETA-CARBOLINE-3-CARBOXYLATE IN A LIGHT DARK CHOICE SITUATION [J].