PROMOTION OF SCIATIC-NERVE REGENERATION IN RATS BY A NEW NEUROTROPHIC PYRIMIDINE DERIVATIVE MS-430

被引：20

作者：

OCHI, M

NODA, M

NAKAMITSU, K

DEIE, M

IKUTA, Y

MAKI, Y

AWAYA, A

机构：

[1] NIIGATA HAND SURG FDN,NIIGATA 950,JAPAN

[2] MITSUI PHARMACEUT INC,DEPT NEW PROD PLANNING,CHIYODA KU,TOKYO,JAPAN

来源：

GENERAL PHARMACOLOGY | 1995年 / 26卷 / 01期

关键词：

PERIPHERAL NERVE; NEW DRUG; NEUROTROPHIC EFFECT;

D O I：

10.1016/0306-3623(94)00149-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effects of a new neurotrophic pyrimidine derivative of MS-430 on nerve regeneration was examined using Wistar rats whose left sciatic nerve had been subjected to controlled injury. 2. The functional recovery and the packing density of common peroneal nerve axons were significantly enhanced with the administration of 3 mg/kg/day of MS-430. 3. These results suggest that MS-430 is a promising candidate as a neurotrophic drug for clinical use.

引用

页码：59 / 64

页数：6

共 28 条

[1]

AWAYA A, 1993, BIOL PHARM BULL, V16, P248

[2]

AWAYA A, 1989, Patent No. 305

[3] ULTRASTRUCTURAL-STUDY OF EFFECT OF ACTH4-10 ON NERVE REGENERATION - AXONS BECOME LARGER IN NUMBER AND SMALLER IN DIAMETER [J].