ETHANOL ENHANCEMENT OF THE MOTOR-STIMULATING EFFECT OF NICOTINE IN THE RAT

被引：11

作者：

LAPIN, EP

MAKER, HS

BHARDWAJ, A

机构：

[1] BETH ISRAEL MED CTR, DEPT NEUROL, NEW YORK, NY 10003 USA

[2] MT SINAI MED CTR, DEPT NEUROL, NEW YORK, NY 10029 USA

来源：

ALCOHOL | 1995年 / 12卷 / 03期

关键词：

NICOTINE-ETHANOL INTERACTION; NICOTINE-INDUCED ROTATION; LESIONS OF THE SUBSTANTIA NIGRA; ETHANOL ENHANCEMENT OF NICOTINE;

D O I：

10.1016/0741-8329(94)00097-W

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Although ethanol stimulates locomotion in mice, it has been difficult to demonstrate such an action in rats. In contrast, nicotine has been shown to enhance locomotion, including ipsiversive rotation in nigral-lesioned rats. We found no significant effect of ethanol alone on rat rotation at doses of 0.125, 0.50, 1.0, and 2.0 g/kg, IP, during a 30-min observation period. However, there was a dose-dependent effect of ethanol enhancing the rotation induced by nicotine (0.4 mg/kg, SC) given 30 min after the ethanol. The interaction of ethanol and nicotine on locomotion most likely involves the release of dopamine and may be related to the motor abnormalities sometimes seen clinically.

引用

页码：217 / 220

页数：4

共 44 条

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