LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY OF ANTISENSE OLIGONUCLEOTIDES

被引：30

作者：

BOTHNER, B ^{[1
]}

CHATMAN, K ^{[1
]}

SARKISIAN, M ^{[1
]}

SIUZDAK, G ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 23期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0960-894X(95)00499-J

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The development of rapid, simple and accurate methods for characterizing and insuring the integrity of oligonucleotides is important for the development of therapeutic and diagnostic products. This study was performed to determine the utility of high performance liquid chromatography (HPLC) with electrospray ionization mass spectrometry detection (LCMS) as an alternative or addition to the current techniques of HPLC, capillary electrophoresis and gel electrophoresis.

引用

页码：2863 / 2868

页数：6

共 12 条

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