STRUCTURAL STUDIES ON BIO-ACTIVE COMPOUNDS .15. STRUCTURE-ACTIVITY-RELATIONSHIPS FOR PYRIMETHAMINE AND A SERIES OF DIAMINOPYRIMIDINE ANALOGS VERSUS BACTERIAL DIHYDROFOLATE-REDUCTASE

被引：24

作者：

SANSOM, CE ^{[1
]}

SCHWALBE, CH ^{[1
]}

LAMBERT, PA ^{[1
]}

GRIFFIN, RJ ^{[1
]}

STEVENS, MFG ^{[1
]}

机构：

[1] UNIV ASTON,DEPT PHARMACEUT SCI,INST PHARMACEUT SCI,ASTON TRIANGLE,BIRMINGHAM B4 7ET,W MIDLANDS,ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1989年 / 995卷 / 01期

关键词：

D O I：

10.1016/0167-4838(89)90228-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：21 / 27

页数：7

共 28 条

[1] CONFORMATIONAL ENERGY CALCULATIONS AND ELECTROSTATIC POTENTIALS OF DIHYDROFOLATE-REDUCTASE LIGANDS - RELEVANCE TO MODE OF BINDING AND SPECIES SPECIFICITY [J].

ANDREWS, PR ;

SADEK, M ;

SPARK, MJ ;

WINKLER, DA .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (05) :698-708

[2]

BAKER DJ, 1983, CHEM BIOL PTERIDINES, P545

[3] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES [J].

BERNSTEIN, FC ;

KOETZLE, TF ;

WILLIAMS, GJB ;

MEYER, EF ;

BRICE, MD ;

RODGERS, JR ;

KENNARD, O ;

SHIMANOUCHI, T ;

TASUMI, M .

JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) :535-542

[4]

BERTINO J R, 1964, Methods Med Res, V10, P297

[5] STRUCTURAL STUDIES ON BIOACTIVE COMPOUNDS .5. SYNTHESIS AND PROPERTIES OF 2,4-DIAMINOPYRIMIDINE DIHYDROFOLATE-REDUCTASE INHIBITORS BEARING LIPOPHILIC AZIDO GROUPS [J].

BLISS, EA ;

GRIFFIN, RJ ;

STEVENS, MFG .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1987, (10) :2217-2228

[6]

BOLIN JT, 1982, J BIOL CHEM, V257, P13650

[7]

BRYANT P J, 1986, P1005

[8]

DAVIES K, 1988, CHEM X DEVELOPED DIS

[9]

FUKAYO M, 1982, ACTA CRYSTALLOGR B, V38, P640

[10]

Gready J E, 1980, Adv Pharmacol Chemother, V17, P37, DOI 10.1016/S1054-3589(08)60007-1

← 1 2 3 →