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OPIOID PEPTIDES MODULATE LUTEINIZING-HORMONE SECRETION DURING SEXUAL-MATURATION

被引：242
作者：
BLANK, MS
PANERAI, AE
FRIESEN, HG
机构：
[1] Department of Physiology, University of Manitoba, Faculty of Medicine, Winnipeg
来源：
SCIENCE | 1979年 / 203卷 / 4385期
关键词：
D O I：
10.1126/science.424743
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Subcutaneous injections of naloxone, an opiate antagonist, lead to an increase in serum luteinizing hormone concentrations in female but not in male rats before they reach puberty. In addition, estradiol benzoate specifically blocks the luteinizing hormone response to naloxone in prepubertal female rats, suggesting that the opioid peptides have a physiological role in the endocrine events leading to sexual maturation. Copyright © 1979 AAAS.
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页码：1129 / 1131
页数：3
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