EFFECTS OF D-AMPHETAMINE AND FRONTAL ABLATIONS ON RESPONSE SUPPRESSION IN RATS

Analyzed the effect of frontal ablations and administration of d-amphetamine on the conditioned emotional response (CER) component of response suppression, as distinct from effects on the operant response per se. In Exp. I, lever pressing was superimposed upon preoperant CER conditioning in 90 naive female Holtzman albino rats. It was found that both frontal ablations and d-amphetamine increased resistance to extinction of response suppression. In Exp. II, the CER was superimposed upon the response of running in a wheel in 90 female Holtzman albino rats. It was found that both frontal ablations and d-amphetamine facilitated suppression learning and later performance. Inverted U dose-response curves for d-amphetamine were obtained in both experiments. (PsycINFO Database Record (c) 2006 APA, all rights reserved). © 1969 American Psychological Association.