RAPID-DETERMINATION OF BENZALKONIUM CHLORIDE IN PHARMACEUTICAL PREPARATIONS WITH FLOW-INJECTION LIQUID-LIQUID-EXTRACTION

被引：16

作者：

HALVAX, JJ ^{[1
]}

WIESE, G ^{[1
]}

ARP, JA ^{[1
]}

VERMEER, JMP ^{[1
]}

VANBENNEKOM, WP ^{[1
]}

BULT, A ^{[1
]}

机构：

[1] PHARMACHEM BV,2003 RN HAARLEM,NETHERLANDS

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1990年 / 8卷 / 03期

关键词：

Benzalkonium chloride assay; flow injection extraction; HPLC method; ion-pair extraction; pharmaceutical preparations;

D O I：

10.1016/0731-7085(90)80033-L

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Benzalkonium chloride was assayed by on-line extraction of the benzalkonium ion with picrate to chloroform. The absorbance of picrate was measured. The extractions were performed with a home-made flow injection extraction unit. Calibration curves (1.5-180 × 10-4% w/v) were straight lines (r = 0.9993) and the relative standard deviation of a series of injections was ≤2%. Pharmaceutical benzalkonium preparations, containing xylometazoline, timolol, phenylephrine or carbachol could also be assayed. The method was compared with a modified HPLC assay. © 1990.

引用

页码：243 / 252

页数：10

共 22 条

[1] DIRECT DETERMINATION OF BENZALKONIUM CHLORIDE IN OPHTHALMIC SYSTEMS BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].