HUMAN RECOMBINANT INTERLEUKIN-1-ALPHA INCREASES ELASTASE-LIKE ENZYME IN HUMAN UTERINE CERVICAL FIBROBLASTS

被引：20

作者：

ITO, A

LEPPERT, PC

MORI, Y

机构：

[1] TOKYO COLL PHARM,DEPT BIOCHEM,HACHIOJI,TOKYO 19203,JAPAN

[2] UNIV ROCHESTER,DEPT OBSTET & GYNECOL,ROCHESTER,NY 14627

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1990年 / 30卷 / 04期

关键词：

UTERINE CERVIX; ELASTASE; INTERLEUKINS; PARTURITION; ELASTIN; REPRODUCTIVE BIOLOGY; CONNECTIVE TISSUE;

D O I：

10.1159/000293277

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Production of the elastase-like enzyme, Suc-(Ala)3-p-nitroanilide hydrolase, was examined in human uterine cervical fibroblasts. The metallo-dependent enzyme is present in both media and cellular fractions. Human recombinant interleukin-1-alpha stimulated cells to produce and secrete this elastase-like enzyme. These results suggest that modulation of this enzyme activity by interleukin-1 may play a significant role in the ripening and dilation of the cervix, because elastin is a component of the uterine cervix and its peptides are known to be chemotactic for leukocytes.

引用

页码：239 / 241

页数：3

共 12 条

[1] SYNTHESIS AND ANALYTICAL USE OF A HIGHLY SENSITIVE AND CONVENIENT SUBSTRATE OF ELASTASE [J].