QUINAZOLINES AND 1,4-BENZODIAZEPINES .89. HAPTENS USEFUL IN BENZODIAZEPINE IMMUNOASSAY DEVELOPMENT

被引：11

作者：

EARLEY, JV ^{[1
]}

FRYER, RI ^{[1
]}

NING, RY ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE INC,DEPT CHEM RES,NUTLEY,NJ 07110

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 07期

关键词：

Benzodiazepines—chemical synthesis; potentially useful haptens; Haptens—benzodiazepines; chemical synthesis; Tranquilizers—benzodiazepines; various;

D O I：

10.1002/jps.2600680715

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses of some 1,4‐benzodiazepines potentially useful as haptens are reported. These compounds are related to chlordiazepoxide, diazepam, nitrazepam, clonazepam, and some of their metabolites. The chemistry reported here is intended to support specific immunoassay development for these drugs. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：845 / 850

页数：6

共 20 条

[1] DRUG IMMUNOASSAYS
BUTLER, VP
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1975, 7 (01) : 1 - 24
[2] RADIOIMMUNOASSAY OF CHLORDIAZEPOXIDE IN PLASMA
DIXON, WR
EARLEY, J
POSTMA, E
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1975, 64 (06) : 937 - 939
[3] DIXON WR, 1975, PHARMACOLOGIST, V17, P251
[4] ESCHENHOF E, 1973, ARZNEIMITTELFORSCH, V23, P390
[5] Garattini S., 1973, BENZODIAZEPINES
[6] Greenblatt D. J., 1974, BENZODIAZEPINES CLIN
[7] METABOLISM OF DIAZEPAM IN RABBITS
JOMMI, G
MANITTO, P
SILANOS, MA
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1964, 108 (02) : 334 - &
[8] RADIOIMMUNOASSAY OF DRUGS - REVIEW
LANDON, J
MOFFAT, AC
[J]. ANALYST, 1976, 101 (1201) : 225 - 243
[9] SUBSTITUENT INTERACTIONS IN ORTHO-SUBSTITUTED NITROBENZENES .4.
LOUDON, JD
TENNANT, G
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1962, (AUG): : 3092 - &
[10] PESKAR B, 1973, J PHARMACOL EXP THER, V186, P167

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