ENZYMATIC-SYNTHESIS OF DIDEOXYRIBONUCLEOSIDES

被引：11

作者：

BETBEDER, D

HEATH, CM

HUTCHINSON, DW

机构：

[1] Department of Chemistry, University of Warwick, Coventry

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 1-3期

关键词：

D O I：

10.1080/07328319108046499

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two N-deoxyribosyltransferases from Lactobacillus leichmanii have been purified and the amino acids involved in the catalysis of the transfer reaction determined. A crude mixture of the transferases have been used to synthesise a purine 2',5'-dideoxynucleoside in high yield.

引用

页码：465 / 468

页数：4

共 8 条

[1] THE STEREOSELECTIVE ENZYMATIC-SYNTHESIS OF 9-BETA-D-2'-DEOXYRIBOFURANOSYL 1-DEAZAPURINE [J].

BETBEDER, D ;

HUTCHINSON, DW ;

RICHARDS, AO .

NUCLEIC ACIDS RESEARCH, 1989, 17 (11) :4217-4222

[2]

BETBEDER D, 1990, IN PRESS NUCLEOSIDES

[3]

BETBEDER D, 1990, IN PRESS ANTIVIRAL C

[4]

CHAWDHRI RF, 1990, UNPUB ARCH MCIROBIOL

[5]

HEATH CM, 1990, UNPUB EUROPEAN J BIO

[6] IMIDAZO[4,5-C]PYRIDINES (3-DEAZAPURINES) AND THEIR NUCLEOSIDES AS IMMUNOSUPPRESSIVE AND ANTIINFLAMMATORY AGENTS [J].

KRENITSKY, TA ;

RIDEOUT, JL ;

CHAO, EY ;

KOSZALKA, GW ;

GURNEY, F ;

CROUCH, RC ;

COHN, NK ;

WOLBERG, G ;

VINEGAR, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (01) :138-143

[7]

Moffatt JG, 1979, NUCLEOSIDE ANALOGUES, P71

[8]

YEAGER RE, 1986, J NEUROCHEM, V47, P139

← 1 →