TRANSIENT MYELOPROLIFERATIVE DISORDER OF THE DOWN TYPE IN THE NORMAL NEWBORN

被引:43
作者
RIDGWAY, D
BENDA, GI
MAGENIS, E
ALLEN, L
SEGAL, GM
BRAZIEL, RM
NEERHOUT, RC
机构
[1] OREGON HLTH SCI UNIV,DEPT MED,DIV HEMATOL & MED ONCOL,PORTLAND,OR 97201
[2] OREGON HLTH SCI UNIV,DEPT PATHOL,PORTLAND,OR 97201
[3] OREGON HLTH SCI UNIV,DOERNBACHER MEM HOSP CHILDREN,PORTLAND,OR 97201
[4] OREGON HLTH SCI UNIV,DIV CRIPPLED CHILDRENS,PORTLAND,OR 97201
来源
AMERICAN JOURNAL OF DISEASES OF CHILDREN | 1990年 / 144卷 / 10期
关键词
D O I
10.1001/archpedi.1990.02150340063024
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
TWo infants with congenital nonlymphoblastic leukemia were discovered to have mosaicism for trisomy 21. Both infants achieved durable spontaneous remissions. Trisomy was apparently restricted to the leukemic clone and could be detected in neither phytohemagglutinin-stimulated peripheral blood cells or bone marrow in either patient nor in myeloid progenitor cells from the second patient after resolution of the transient myeloproliferative disorder. We conclude that spontaneous remission of congenital leukemia is not confined to infants with partial or complete systemic trisomy 21 but can occur in genetically normal new-borns whose leukemic cells contain a third chromosome 21. © 1990, American Medical Association. All rights reserved.
引用
收藏
页码:1117 / 1119
页数:3
相关论文
共 15 条
[1]  
BRODEUR GM, 1980, BLOOD, V55, P691
[2]   LEUKEMIA IN A TRISOMY-21 MOSAIC - SPECIFIC INVOLVEMENT OF THE TRISOMIC CELLS [J].
FERSTER, A ;
VERHEST, A ;
VAMOS, E ;
DEMAERTELAERE, E ;
OTTEN, J .
CANCER GENETICS AND CYTOGENETICS, 1986, 20 (1-2) :109-113
[3]  
GRANICK DJ, 1986, CRIT REV ONCOL HEMAT, V6, P55
[4]  
HANNA MD, 1985, AM J PEDIAT HEMATOL, V7, P79
[5]  
HEATON DC, 1981, BLOOD, V57, P883
[6]  
LAMPKIN BC, 1985, AM J PEDIAT HEMATOL, V7, P346
[7]   CORRELATION BETWEEN CYTOGENETIC AND MOLECULAR FINDINGS IN HUMAN CHRONIC MYELOGENOUS LEUKEMIA LINE-EM-2 AND LINE-EM-3 [J].
RASKIND, WH ;
DISTECHE, CM ;
KEATING, A ;
SINGER, JW .
CANCER GENETICS AND CYTOGENETICS, 1987, 25 (02) :271-284
[8]  
ROWLEY JD, 1981, LANCET, V2, P1020
[9]   MONGOLISM AND CONGENITAL LEUKEMIA [J].
SCHUNK, GJ ;
LEHMAN, WL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1954, 155 (03) :250-251
[10]  
SEGAL GM, 1989, BLOOD, V72, P1364