THE ROLE OF PROTEIN-KINASE-C IN MIGRATION OF RAT GLIOMA-CELLS FROM SPHEROID CULTURES

被引：21

作者：

JANIK, P

SZANIAWSKA, B

MILOSZEWSKA, J

PIETRUSZEWSKA, E

KOWALCZYK, D

机构：

[1] Department of Tumor Biology, Cancer Center Institute of Oncology, 00-973 Warsaw

来源：

CANCER LETTERS | 1992年 / 63卷 / 02期

关键词：

PROTEIN KINASE-C; CELL MIGRATION; GLIOMA;

D O I：

10.1016/0304-3835(92)90067-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of protein kinase C in migration of tumor cells from spheroid cultures was investigated using parental rat glioma cells and their TPA resistant counterparts. These two lines differed in their PKC content as judged by the histone phosphorylation method. Also 4 days of treatment with IRA led to PKC down-regulation. Cells having a drastically decreased PKC level migrated better then those having a normal PKC content.

引用

页码：167 / 170

页数：4

共 13 条

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