INFLUENCE OF THE CONSUMPTION OF MEAT CONTAMINATED WITH ANABOLIC-STEROIDS ON DOPING TESTS

被引:31
作者
DEBRUYCKERE, G [1 ]
VANPETEGHEM, CH [1 ]
DESAGHER, R [1 ]
机构
[1] STATE UNIV GHENT,FAC PHARMACEUT SCI,ANALYT CHEM LAB,B-9000 GHENT,BELGIUM
关键词
GAS CHROMATOGRAPHY; MASS SPECTROMETRY; ANABOLIC STEROIDS; CLOSTEBOL; DOPING; MEAT; NANDROLONE;
D O I
10.1016/0003-2670(93)80275-P
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
In 1989, 3 cases out of 20 were found where gas chromatography-mass spectrometry revealed the presence of nandrolone metabolites in the urine of untreated persons. Although the origin of the nandrolone metabolites was uncertain at that time, the presumption was that such findings could be related to the consumption of meat from nandrolone-treated animals. Two years later, in a feeding experiment with volunteers, 1 out of 10 persons was positive for clostebol due to the accidental consumption of meat contaminated with clostebol acetate. In 1992, a similar random experiment was carried out (n = 50), yielding 2 positive cases (1 nandrolone case and 1 clostebol case). The urinary concentrations found in the volunteers who had accidentally consumed contaminated meat were compared with the levels found in volunteers after a controlled intake of a minor dose of the anabolic steroid concerned. The above levels were also compared with those after intake of a therapeutic dose of the compound.
引用
收藏
页码:49 / 56
页数:8
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