AN IMMUNOGENETIC HETEROGENEITY IN MULTIPLE-SCLEROSIS

被引：71

作者：

HILLERT, J

GRONNING, M

NYLAND, H

LINK, H

OLERUP, O

机构：

[1] UNIV BERGEN,DEPT NEUROL,N-5014 BERGEN,NORWAY

[2] KAROLINSKA INST,HUDDINGE HOSP,DEPT NEUROL,S-14186 HUDDINGE,SWEDEN

[3] KAROLINSKA INST,HUDDINGE HOSP,DEPT CLIN IMMUNOL,S-14186 HUDDINGE,SWEDEN

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1992年 / 55卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1136/jnnp.55.10.887

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two clinical forms of multiple sclerosis (MS), primarily chronic progressive MS (PCP MS) and relapsing/remitting MS (R/R MS) have been shown to differ in several respects. The results of genomic HLA class II typing with restriction fragment length polymorphism analysis of 62 MS patients from Western Norway, 42 with R/R MS and 20 PCP MS, are reported on here. As in previous studies of Swedish patients, the haplotype DRw17(3), DQw2 was found to be five times more common in R/R MS than in PCP MS. This finding supports the hypothesis that R/R and PCP MS are immunogenetically separate entities. In contrast with a previous investigation of Norwegian MS patients, no association of MS with glutamine at position 34 of the HLA-DQalpha chain or with defined sequences of the HLA-DQB1 gene was found.

引用

收藏

页码：887 / 890

页数：4

相关论文

共 30 条

[1] ALLOGENOTYPES DEFINED BY SHORT DQ-ALPHA AND DQ-BETA CDNA PROBES CORRELATE WITH AND DEFINE SPLITS OF HLA-DQ SEROLOGICAL SPECIFICITIES [J].

BIDWELL, JL ;

BIDWELL, EA ;

LAUNDY, GJ ;

KLOUDA, PT ;

BRADLEY, BA .

MOLECULAR IMMUNOLOGY, 1987, 24 (05) :513-522

[2] HLA-DR-DQ HAPLOTYPES DEFINED BY RESTRICTION FRAGMENT ANALYSIS - CORRELATION TO SEROLOGY [J].

CARLSSON, B ;

WALLIN, J ;

BOHME, J ;

MOLLER, E .

HUMAN IMMUNOLOGY, 1987, 20 (02) :95-113

[3] COURSE AND PROGNOSIS OF MULTIPLE-SCLEROSIS ASSESSED BY THE COMPUTERIZED DATA-PROCESSING OF 349 PATIENTS [J].

CONFAVREUX, C ;

AIMARD, G ;

DEVIC, M .

BRAIN, 1980, 103 (JUN) :281-300

[4] HLA-DR AND HLA-DQ DNA GENOTYPING IN MULTIPLE-SCLEROSIS PATIENTS IN NORTHERN-IRELAND [J].

CULLEN, CG ;

MIDDLETON, D ;

SAVAGE, DA ;

HAWKINS, S .

HUMAN IMMUNOLOGY, 1991, 30 (01) :1-6

[5] EXACERBATION RATES AND ADHERENCE TO DISEASE TYPE IN A PROSPECTIVELY FOLLOWED-UP POPULATION WITH MULTIPLE-SCLEROSIS - IMPLICATIONS FOR CLINICAL-TRIALS [J].

GOODKIN, DE ;

HERTSGAARD, D ;

RUDICK, RA .

ARCHIVES OF NEUROLOGY, 1989, 46 (10) :1107-1112

[6] THE SHARED EPITOPE HYPOTHESIS - AN APPROACH TO UNDERSTANDING THE MOLECULAR-GENETICS OF SUSCEPTIBILITY TO RHEUMATOID-ARTHRITIS [J].

GREGERSEN, PK ;

SILVER, J ;

WINCHESTER, RJ .

ARTHRITIS AND RHEUMATISM, 1987, 30 (11) :1205-1213

[7]

GUDMUNDSSON KR, 1971, ACTA NEUROL SCAN S48, V47, P1

[8] RESTRICTION FRAGMENT LENGTH POLYMORPHISM (RFLP) OF A NEW HLA-DP SPECIFICITY, CDP-HEI [J].

HYLDIGNIELSEN, JJ ;

ODUM, N ;

MORLING, N ;

SVEJGAARD, A .

TISSUE ANTIGENS, 1988, 31 (03) :161-163

[9] RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM OF THE HLA-DP SUBREGION AND CORRELATIONS TO HLA-DP PHENOTYPES [J].

HYLDIGNIELSEN, JJ ;

MORLING, N ;

ODUM, N ;

RYDER, LP ;

PLATZ, P ;

JAKJAKOBSEN, B ;

SVEJGAARD, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (06) :1644-1648

[10] SEQUENCE-ANALYSIS OF HLA-DR4B1 SUBTYPES - ADDITIONAL 1ST DOMAIN VARIABILITY IS DETECTED BY OLIGONUCLEOTIDE HYBRIDIZATION AND NUCLEOTIDE SEQUENCING [J].

LANCHBURY, JSS ;

HALL, MA ;

WELSH, KI ;

PANAYI, GS .

HUMAN IMMUNOLOGY, 1990, 27 (02) :136-144