PETROSYNOL AND PETROSOLIC ACID, 2 NOVEL NATURAL INHIBITORS OF THE REVERSE-TRANSCRIPTASE OF HUMAN-IMMUNODEFICIENCY-VIRUS FROM PETROSIA SP

被引：60

作者：

ISAACS, S

KASHMAN, Y

LOYA, S

HIZI, A

LOYA, Y

机构：

[1] TEL AVIV UNIV,SCH CHEM,IL-69978 TEL AVIV,ISRAEL

[2] TEL AVIV UNIV,SCH MED,IL-69978 TEL AVIV,ISRAEL

[3] TEL AVIV UNIV,DEPT ZOOL,IL-69978 TEL AVIV,ISRAEL

来源：

TETRAHEDRON | 1993年 / 49卷 / 45期

关键词：

D O I：

10.1016/S0040-4020(01)80571-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two potyacetylenes from the Red Sea sponge Petrosia sp., Petrosynol (1), and the novel marine natural product petrosolic acid (2) were found effective in inhibitory of the DNA polymerase activities of the reverse transcriptase of human immunodeficiency virus. The structure of compound 2 a novel C44 oxo-octahydroxy-trienetetraynoic carboxylic acid was determined mainly by NMR spectroscopy.

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页码：10435 / 10438

页数：4

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