INSULIN-RESISTANCE AND LIPOPROTEIN METABOLISM

被引：136

作者：

TASKINEN, MR ^{[1
]}

机构：

[1] HELSINKI UNIV, CENT HOSP, DEPT MED, SF-00290 HELSINKI, FINLAND

来源：

CURRENT OPINION IN LIPIDOLOGY | 1995年 / 6卷 / 03期

关键词：

D O I：

10.1097/00041433-199506000-00007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dyslipidaemia in insulin resistance comprises elevated plasma triglycerides, decreased HDL, a preponderance of small, dense LDL and increased postprandial lipaemia. In terms of cause and effect, small, dense LDL, alimentary hyperlipidaemia and changes in HDL are consequences of elevated triglycerides. These abnormalities can become frequent if triglycerides exceed a threshold value of approximately 1.5 mmol/l. Therefore, it is mandatory to maintain plasma triglycerides as low as possible in noninsulin-dependent diabetic and insulin-resistant individuals to prevent the potentially atherogenic and metabolic consequences of hypertriglyceridaemia.

引用

页码：153 / 160

页数：8

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