INSULIN-RESISTANCE AND LIPOPROTEIN METABOLISM

被引：135

作者：

TASKINEN, MR ^{[1
]}

机构：

[1] HELSINKI UNIV, CENT HOSP, DEPT MED, SF-00290 HELSINKI, FINLAND

来源：

CURRENT OPINION IN LIPIDOLOGY | 1995年 / 6卷 / 03期

关键词：

D O I：

10.1097/00041433-199506000-00007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dyslipidaemia in insulin resistance comprises elevated plasma triglycerides, decreased HDL, a preponderance of small, dense LDL and increased postprandial lipaemia. In terms of cause and effect, small, dense LDL, alimentary hyperlipidaemia and changes in HDL are consequences of elevated triglycerides. These abnormalities can become frequent if triglycerides exceed a threshold value of approximately 1.5 mmol/l. Therefore, it is mandatory to maintain plasma triglycerides as low as possible in noninsulin-dependent diabetic and insulin-resistant individuals to prevent the potentially atherogenic and metabolic consequences of hypertriglyceridaemia.

引用

页码：153 / 160

页数：8

共 69 条

[1] RELATIONSHIPS BETWEEN PLASMA-LIPOPROTEIN CONCENTRATIONS AND INSULIN ACTION IN AN OBESE HYPERINSULINEMIC POPULATION [J].

ABBOTT, WGH ;

LILLIOJA, S ;

YOUNG, AA ;

ZAWADZKI, JK ;

YKIJARVINEN, H ;

CHRISTIN, L ;

HOWARD, BV .

DIABETES, 1987, 36 (08) :897-904

[2] INCREASED PLASMA CHOLESTERYL ESTER TRANSFER PROTEIN IN OBESE SUBJECTS - A POSSIBLE MECHANISM FOR THE REDUCTION OF SERUM HDL CHOLESTEROL LEVELS IN OBESITY [J].

ARAI, T ;

YAMASHITA, S ;

HIRANO, KI ;

SAKAI, N ;

KOTANI, K ;

FUJIOKA, S ;

NOZAKI, S ;

KENO, Y ;

YAMANE, M ;

SHINOHARA, E ;

ISLAM, AHMW ;

ISHIGAMI, M ;

NAKAMURA, T ;

KAMEDATAKEMURA, K ;

TOKUNAGA, K ;

MATSUZAWA, Y .

ARTERIOSCLEROSIS AND THROMBOSIS, 1994, 14 (07) :1129-1136

[3] SMOKING INDUCES INSULIN RESISTANCE - A POTENTIAL LINK WITH THE INSULIN RESISTANCE SYNDROME [J].

ATTVALL, S ;

FOWELIN, J ;

LAGER, I ;

VONSCHENCK, H ;

SMITH, U .

JOURNAL OF INTERNAL MEDICINE, 1993, 233 (04) :327-332

[4]

Bjorntorp Per, 1994, Current Opinion in Lipidology, V5, P166, DOI 10.1097/00041433-199405030-00003

[5] ACTIVITIES OF LIPOPROTEIN-LIPASE AND HEPATIC TRIGLYCERIDE LIPASE IN POSTHEPARIN PLASMA OF PATIENTS WITH LOW CONCENTRATIONS OF HDL CHOLESTEROL [J].

BLADES, B ;

VEGA, GL ;

GRUNDY, SM .

ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (08) :1227-1235

[6] INFLUENCE OF TRIACYLGLYCEROL BIOSYNTHESIS RATE ON THE ASSEMBLY OF APO-B-100-CONTAINING LIPOPROTEINS IN HEP G2 CELLS [J].

BOREN, J ;

RUSTAEUS, S ;

WETTESTEN, M ;

ANDERSSON, M ;

WIKLUND, A ;

OLOFSSON, SO .

ARTERIOSCLEROSIS AND THROMBOSIS, 1993, 13 (12) :1743-1754

[7] HYPERTRIGLYCERIDEMIA IN SUBJECTS WITH NORMAL AND ABNORMAL GLUCOSE-TOLERANCE - RELATIVE CONTRIBUTIONS OF INSULIN-SECRETION, INSULIN-RESISTANCE AND SUPPRESSION OF PLASMA NONESTERIFIED FATTY-ACIDS [J].

BYRNE, CD ;

WAREHAM, NJ ;

BROWN, DC ;

CLARK, PMS ;

COX, LJ ;

DAY, NE ;

PALMER, CR ;

WANG, TWM ;

WILLIAMS, DRR ;

HALES, CN .

DIABETOLOGIA, 1994, 37 (09) :889-896

[8] POSTPRANDIAL AMPLIFICATION OF LIPOPROTEIN ABNORMALITIES IN CONTROLLED TYPE-II DIABETIC SUBJECTS - RELATIONSHIP TO POSTPRANDIAL LIPEMIA AND C-PEPTIDE GLUCAGON-LEVELS [J].

CAVALLERO, E ;

DACHET, C ;

NEUFCOUR, D ;

WIRQUIN, E ;

MATHE, D ;

JACOTOT, B .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1994, 43 (03) :270-278

[9] PARTICLE-SIZE DISTRIBUTION OF HIGH-DENSITY LIPOPROTEINS AS A FUNCTION OF PLASMA TRIGLYCERIDE CONCENTRATION IN HUMAN-SUBJECTS [J].

CHANG, LBF ;

HOPKINS, GJ ;

BARTER, PJ .

ATHEROSCLEROSIS, 1985, 56 (01) :61-70

[10] INTESTINALLY-DERIVED LIPOPROTEINS - METABOLISM AND CLINICAL-SIGNIFICANCE [J].

CHEN, YDI ;

REAVEN, GM .

DIABETES-METABOLISM REVIEWS, 1991, 7 (03) :191-208

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