DIRECT RESOLUTION OF NAPROXEN ON A NONCOVALENTLY MOLECULARLY IMPRINTED CHIRAL STATIONARY-PHASE

被引：207

作者：

KEMPE, M ^{[1
]}

MOSBACH, K ^{[1
]}

机构：

[1] LUND UNIV,S-22100 LUND,SWEDEN

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 664卷 / 02期

关键词：

D O I：

10.1016/0021-9673(94)87016-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.

引用

页码：276 / 279

页数：4

共 27 条

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