POSSIBLE PATHOGENIC ROLE OF IGE IN HENOCH-SCHONLEIN PURPURA

被引:28
作者
DAVIN, JC
PIERARD, G
DECHENNE, C
GROSSMAN, D
NAGY, J
QUACOE, M
MALAISE, M
HALL, M
JANSEN, F
CHANTRAINE, JM
MAHIEU, PR
机构
[1] STATE UNIV LIEGE,DEPT IMMUNOL TRANSPLANTAT,B-4000 LIEGE,BELGIUM
[2] STATE UNIV LIEGE,DEPT DERMATOPATHOL,B-4000 LIEGE,BELGIUM
[3] UNIV PECZ,DEPT PATHOL,PECZ,HUNGARY
[4] FREE UNIV BRUSSELS,PAEDIAT NEPHROL UNIT,B-1050 BRUSSELS,BELGIUM
关键词
ATOPY; IGA NEPHROPATHY; HENOCH-SCHONLEIN PURPURA; IGE;
D O I
10.1007/BF00865470
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The incidences of clinical and biological markers of atopy were investigated in 16 children with IgA nephropathy (IgAN) (group A) and in 22 with Henoch-Schonlein purpura nephritis (HSPN) (group B). The incidence of increased plasma IgE levels according to age-matched normal values was significantly higher in group B (17/22, 77%) than in group A (7/16, 44%) (P <0.05). Although not significant, the incidences of positive RAST tests and of a history of typical atopic symptoms were also higher in group B [10/22 (45%) and 11/22 (50%), respectively] than in group A [4/16 (25%) and 5/16 (31%), respectively]. Moreover, IgE deposits were demonstrated by a peroxidase/anti-peroxidase method on cutaneous Langerhans and mast cells in 4 of 6 patients with HSPN. Thus immunoallergy might account, in some cases, for the cutaneous, intestinal and pulmonary signs observed in HSPN, but not in IgAN. We postulate stimulation of IgE-sensitized mast cells by specific antigens in the presence of IgA circulating immune complexes (CIC), release of vasoactive substances, increased capillary permeability and perivascular deposition of IgA CIC.
引用
收藏
页码:169 / 171
页数:3
相关论文
共 22 条
[1]  
Nakamoto Y., Asamo Y., Dahi K., Fujioka M., Ida H., Keda H., Kibe Y., Hattori N., Takeuchi S., Primary IgA glomerulonephritis and Schönlein-Henoch purpura nephritis: clinicopathoological and immunological characteristics, Q J Med, 47, pp. 495-516, (1978)
[2]  
Weiss J.H., Bhathena D.B., Curtis J.J., A possible relationship between Henoch-Schönlein syndrome and IgA nephropathy (Berger's disease), Lancet, 1, (1975)
[3]  
Meadow S.R., Scott D.G., Berger's disease: Henoch-Schönlein syndrome without the rash, J Pediatr, 106, pp. 27-32, (1985)
[4]  
Emancipator S.E., Primary and secondary forms of IgA nephritis, Schönlein-Henoch syndrome, Pathology of the kidney, pp. 389-476, (1992)
[5]  
Van Es L.A., Kauffmann R.H., Valentijn R.M., Renal manifestations of systemic diseases. Henoch-Schönlein purpura, Pediatric Nephrology, pp. 492-498, (1987)
[6]  
Sa W.M., Human hypersensitivity angiitis, an immune complex disease, J Invest Dermatol, 85, pp. 144S-148S, (1985)
[7]  
Tosca N., Stratigos J.D., Possible pathogenetic mechanisms in allergic cutaneous vaculitis, Int J Dermatol, 27, pp. 291-296, (1988)
[8]  
Faille-Kuyper E.H., van der Meer J.R., Kater L., Mul N., Alternate pathology complement activation by IgA in Schönlein-Henoch syndrome, Neth J Med, 17, pp. 5-9, (1974)
[9]  
Faille-Kuyper E.H., Kater L., Kuitjen R.H., Kooiker C.J., Wagenaar S.S., Van der Zowen P., Doorhaut Mees E.J., Occurrence of vascular IgA deposits in clinically normal skin of patients with renal disease, Kidney Int, 9, pp. 424-429, (1976)
[10]  
Braverman I.M., Yen A., Demonstration of immune complexes in spontaneous and histamine-induced lesions and in normal skin of patients with leucocytoclastic angiitis, J Invest Dermatol, 64, pp. 105-112, (1975)