STRUCTURE AND RELATIVE STEREOCHEMISTRY OF A NEW POLYCYCLIC ALKALOID, ASPARAGAMINE-A, SHOWING ANTI-OXYTOCIN ACTIVITY, ISOLATED FROM ASPARAGUS-RACEMOSUS

被引：49

作者：

SEKINE, T

IKEGAMI, F

FUKASAWA, N

KASHIWAGI, Y

AIZAWA, T

FUJII, Y

RUANGRUNGSI, N

MURAKOSHI, I

机构：

[1] CHIBA UNIV,FAC PHARMACEUT SCI,INAGE KU,CHIBA 263,JAPAN

[2] TSUMURA & CO,CHIYODA KU,TOKYO 102,JAPAN

[3] CHULALONGKORN UNIV,FAC PHARMACEUT SCI,BANGKOK 10330,THAILAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 04期

关键词：

D O I：

10.1039/p19950000391

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The relative stereochemistry of a new cage-type alkaloid, asparagamine A 1. isolated from the roots of Asparagus racemosus Willd. (Liliaceae). has been elucidated by spectroscopic, chemical and single-crystal X-ray analyses. This novel polycyclic pyrrolizidine derivative is both the first alkaloid to be isolated from this genus and also the first pyrrolizidine derivative with carbon substituents at C-5 and C-8. The compound showed anti-oxytocin activity in vitro in a dose of 10(-5)-10(-6) mg cm(-3).

引用

页码：391 / 393

页数：3

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