EARLY EVENTS IN INOSITOL PHOSPHATE-METABOLISM IN LONGITUDINAL SMOOTH-MUSCLE FROM GUINEA-PIG INTESTINE STIMULATED WITH CARBACHOL

被引：27

作者：

SALMON, DMW ^{[1
]}

BOLTON, TB ^{[1
]}

机构：

[1] ST GEORGES HOSP, SCH MED, DEPT PHARMACOL, CRANMER TERRACE, LONDON SW17 0RE, ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1988年 / 254卷 / 02期

关键词：

D O I：

10.1042/bj2540553

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In longitudinal smooth muscle from quinea-pig intestine prelabelled with [3H]inositol, carbachol produced a 3-fold increase in [3H]inositol 1,4,5-trisphosphate within 2 s, and there was also a simultaneous increase in [3H]inositol 1,4-bisphosphate. 3H-labelling of inositol 1,3,4,5-tetrakisphosphate was not significantly increased until 60 s after carbachol stimulation, and the accumulation of [3H]inositol 1,3,4-trisphosphate was relatively small.

引用

页码：553 / 557

页数：5

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