METABOLISM OF LINDANE TO TETRACHLOROBENZENE

In addition to the two previously reportedisomers of pentachlorocyclohexene, the 1,2,4,5-isomer of tetrachlorobenzene as a metabolite of lindane in susceptible and resistant strains of houseflies was tentatively identified. Products having retention times identical to those of 1,2,4- and 1,2,3-trichlorobenzene, 1,2,3,4-tetrachlorobenzene, and pentachlorobenzene were also formed. Application of γ-pentachlorocyclohexane produced only 1,2,4,5-tetrachlorobenzene and 1,2,4-trichlorobenzene, while application of the second isomer of PCCH yielded the five products. Treatment with 1,2,4-trichlorobenzene, 1,2,3,4-and 1,2,4,5-tetrachlorobenzene, or pentachlorobenzene produced no other organic-soluble materials. © 1969, American Chemical Society. All rights reserved.