SERUM FROM INFECTED MICE SUPPRESSES MACROPHAGE-MEDIATED IMMUNITY IN MYCOBACTERIUM-LEPRAEMURIUM INFECTION - MODEL FOR IMPAIRED MACROPHAGE IMMUNITY IN HUMAN LEPROSY

被引：12

作者：

PRESTON, PM ^{[1
]}

机构：

[1] NATL INST MED RES,LONDON NW7 1AA,ENGLAND

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1979年 / 73卷 / 02期

关键词：

D O I：

10.1016/0035-9203(79)90215-3

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Differing patterns of Mycobacterium lepraemurium infection in inbred strains of mice are of interest as a model system for studying mycobacterial infections of man, e.g. M. leprae, which present with a spectrum of clinical disease. In vitro, macrophages from both resistant (C57B1) and susceptible (BALB/c) inbred strains of mice can be shown to be equally effective in controlling multiplication of M. lepraemurium. Experiments presented here show that in vivo, the potential mechanisms of macrophage-mediated immunity are suppressed in the susceptible (BALB/c) strain of mouse by a soluble factor(s) present in the serum and the peritoneal fluid of infected mice. © 1979, Royal Society of Tropical Medicine & Hygiene.

引用

页码：212 / 215

页数：4

共 11 条

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