DISSOCIATION OF THE ANTINOCICEPTIVE EFFECT OF CLONIDINE FROM SUPRASPINAL STRUCTURES

被引：100

作者：

SPAULDING, TC

VENAFRO, JJ

MA, MG

FIELDING, S

机构：

来源：

NEUROPHARMACOLOGY | 1979年 / 18卷 / 01期

关键词：

D O I：

10.1016/0028-3908(79)90015-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The tail flick assay was used to assess the antinociceptive effects of morphine and clonidine in control and T6-T8 spinally transected mice. In spinalized mice the morphine ED50 was increased 4-7 fold while the clonidine ED50 was not significantly altered. These results indicate a clear separation of the principle sites for the antinociceptive activity of morphine and clonidine in this test. © 1979.

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页码：103 / 105

页数：3

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