DIISOBUTYLALUMINUM "2,6-DI-TERT-BUTYL-4-METHYLPHENOXIDE - NOVEL STEREOSELECTIVE REDUCING AGENT FOR PROSTAGLANDIN SYNTHESIS

被引：75

作者：

IGUCHI, S ^{[1
]}

NAKAI, H ^{[1
]}

HAYASHI, M ^{[1
]}

YAMAMOTO, H ^{[1
]}

机构：

[1] UNIV HAWAII,DEPT CHEM,HONOLULU,HI 96822

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 08期

关键词：

D O I：

10.1021/jo01322a045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In an effort to explore the selective reducing agents suitable for prostaglandin synthesis, diisobutylaluminum 2, 6-di-tert-butyl-4-methylphenoxide (1) is found to be among the best. Reduction of the C-15 ketone 2a with 1 in toluene at -78 °C produced the desired-alcohol 3a in 95% yield with 92% stereoselectivity. The procedure is suitable for the syn-p-phenylbenzoyl ester 2d as the substrate. © 1979, American Chemical Society. All rights reserved.

引用

页码：1363 / 1364

页数：2

共 13 条

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