REGIONAL DISTRIBUTION OF IMIPRAMINE, DESIPRAMINE AND SPECIFIC [H-3] DESIPRAMINE BINDING-SITES IN THE RAT-BRAIN AFTER ACUTE AND CHRONIC TREATMENT WITH IMIPRAMINE

被引：12

作者：

DANIEL, W ^{[1
]}

DANEK, L ^{[1
]}

JANCZAR, L ^{[1
]}

NOCON, H ^{[1
]}

MELZACKA, M ^{[1
]}

机构：

[1] POLISH ACAD SCI,INST PHARMACOL,DEPT PHARMACOKINET & DRUG METAB,PL-31343 KRAKOW,POLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 01期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb05443.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Regional distribution of imipramine, desipramine and specific [H-3]desipramine binding sites in the rat brain after acute and chronic treatment of rats with imipramine has been investigated. Both substances were distributed unevenly within rat brain after single and prolonged administration of imipramine. This was partly connected with the regional cerebral blood flow, lipid content in the regions and lipophilicity of the substances investigated. It was also found that the number of specific [H-3]desipramine binding sites was different in the various brain areas, and that prolonged administration of imipramine led to a decrease of their number in some of those regions. No correlation was found between the regional cerebral distribution of desipramine and the regional density of specific [H-3]desipramine binding sites.

引用

页码：31 / 35

页数：5

共 25 条

[1] MODULATION OF NEURONAL SEROTONIN UPTAKE BY A PUTATIVE ENDOGENOUS LIGAND OF IMIPRAMINE RECOGNITION SITES
BARBACCIA, ML
GANDOLFI, O
CHUANG, DM
COSTA, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (16): : 5134 - 5138
[2] BARKAI AI, 1984, J PHARMACOL EXP THER, V230, P330
[3] BICKEL MH, 1968, ARCH INT PHARMACOD T, V173, P433
[4] BINDING OF A LABELED ANTI-DEPRESSANT TO RAT-BRAIN TISSUE
BIEGON, A
SAMUEL, D
[J]. BIOCHEMICAL PHARMACOLOGY, 1979, 28 (23) : 3361 - 3366
[5] BIEGON A, 1983, J NEUROSCI, V3, P1069
[6] BJORKLUND A, 1984, CLASSICAL TRANSMIT 1, P123
[7] BJORKLUND A, 1984, CLASSICAL TRANSMIT 2, P68
[8] CONCOMITANT DECREASE IN [H-3]IMIPRAMINE BINDING IN CAT BRAIN AND PLATELETS AFTER CHRONIC TREATMENT WITH IMIPRAMINE
BRILEY, M
RAISMAN, R
ARBILLA, S
CASADAMONT, M
LANGER, SZ
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1982, 81 (02) : 309 - 314
[9] CEREBRAL PHARMACOKINETICS OF IMIPRAMINE IN RATS AFTER SINGLE AND MULTIPLE DOSAGES
DANIEL, W
ADAMUS, A
MELZACKA, M
SZYMURA, J
VETULANI, J
[J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1981, 317 (03) : 209 - 213
[10] THE ROUTE OF ADMINISTRATION OF IMIPRAMINE AS A FACTOR AFFECTING FORMATION OF ITS METABOLITE DESIPRAMINE
DANIEL, W
ADAMUS, A
MELZACKA, M
SZYMURA, J
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1982, 34 (10) : 678 - 680

← 1 2 3 →