CALMODULIN ACTIVATION OF ADENYLATE-CYCLASE IN PANCREATIC-ISLETS

被引:230
作者
VALVERDE, I
VANDERMEERS, A
ANJANEYULU, R
MALAISSE, WJ
机构
[1] Laboratories of Biochemistry and Experimental Medicine, Brussels University, Brussels
关键词
D O I
10.1126/science.225798
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3′,5′-monophosphate evoked by insulin releasing agents in the islet cells.
引用
收藏
页码:225 / 227
页数:3
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