CALMODULIN ACTIVATION OF ADENYLATE-CYCLASE IN PANCREATIC-ISLETS

被引：230

作者：

VALVERDE, I

VANDERMEERS, A

ANJANEYULU, R

MALAISSE, WJ

机构：

[1] Laboratories of Biochemistry and Experimental Medicine, Brussels University, Brussels

来源：

SCIENCE | 1979年 / 206卷 / 4415期

关键词：

D O I：

10.1126/science.225798

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3′,5′-monophosphate evoked by insulin releasing agents in the islet cells.

引用

页码：225 / 227

页数：3

共 28 条

[1] STIMULUS-SECRETION COUPLING OF GLUCOSE-INDUCED INSULIN RELEASE .7. PROPOSED SITE OF ACTION FOR ADENOSINE-3',5'-CYCLIC MONOPHOSPHATE [J].