CEPHALOSPORIN NITROGEN-MUSTARD CARBAMATE PRODRUGS FOR ADEPT

被引：65

作者：

ALEXANDER, RP ^{[1
]}

BEELEY, NRA ^{[1
]}

ODRISCOLL, M ^{[1
]}

ONEILL, FP ^{[1
]}

MILLICAN, TA ^{[1
]}

PRATT, AJ ^{[1
]}

WILLENBROCK, FW ^{[1
]}

机构：

[1] DYSON PERRINS LAB, OXFORD OX1 3QY, ENGLAND

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 27期

关键词：

ADEPT; BETA-LACTAMASE; MONCLONAL ANTIBODY; NITROGEN MUSTARD; PRODRUG;

D O I：

10.1016/S0040-4039(00)79741-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of cephalosporin carbamates, (6 a-d) and (7), functionalised with masked nitrogen mustards has been synthesised. These are potential prodrugs for interaction with a monoclonal antibody-beta-lactamase tumour targeting system. The beta-lactamase catalysed hydrolysis of (6 a-d) and (7) to generate free nitrogen mustards has been characterised.

引用

页码：3269 / 3272

页数：4

共 17 条

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