STRUCTURE, SEROLOGICAL SPECIFICITY, AND SYNTHESIS OF ARTIFICIAL GLYCOCONJUGATES REPRESENTING THE GENUS-SPECIFIC LIPOPOLYSACCHARIDE EPITOPE OF CHLAMYDIA SPP

被引：98

作者：

HOLST, O

BRADE, L

KOSMA, P

BRADE, H

机构：

[1] FORSCHUNGSINST BORSTEL,INST EXPTL BIOL & MED,DIV BIOCHEM MICROBIOL,PARKALLEE 22,W-2061 BORSTEL,GERMANY

[2] AGR UNIV VIENNA,INST CHEM,A-1180 VIENNA,AUSTRIA

来源：

JOURNAL OF BACTERIOLOGY | 1991年 / 173卷 / 06期

关键词：

D O I：

10.1128/jb.173.6.1862-1866.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The human bacterial pathogens Chlamydia spp. possess a genus-specific lipopolysaccharide as a major surface antigen, the structure of which has been determined by analytical chemistry as Kdop-alpha-2-8-Kdop-alpha-2-4-Kdop-alpha-2-6GlcNp-beta-1-6GlcNol (Kdo, 3-deoxy-D-manno-2-octulosonic acid). Immunochemical studies on this pentasaccharide and the chemically synthesized partial structures Kdop-alpha-2-8-Kdop-alpha-2-4-Kdop-alpha-2-6GlcNp-beta, Kdop-alpha-2-8-Kdop-alpha-2-4-Kdop-alpha, Kdop-alpha-2-4-Kdop-alpha, Kdop-alpha-2-8-Kdop-alpha, and Kdop-alpha using artificial glycoconjugate antigens and monoclonal antibodies showed that fatty acids and phosphoryl groups (as present in native lipopolysaccharide) are dispensable for constitution of the genus-specific epitope and that the minimal structure to exhibit chlamydia specificity is the Kdo trisaccharide moiety.

引用

页码：1862 / 1866

页数：5

共 25 条

[1] STRUCTURAL ELUCIDATION OF 3-DEOXY-D-MANNO-OCTULOSONIC ACID CONTAINING MENINGOCOCCAL 29-E CAPSULAR POLYSACCHARIDE ANTIGEN USING C-13 NUCLEAR MAGNETIC-RESONANCE [J].