DELAYED SPONTANEOUS PUBERTAL GROWTH SPURT IN GIRLS WITH THE ULLRICH-TURNER SYNDROME

被引：10

作者：

PELZ, L

SAGER, G

HINKEL, GK

KIRCHNER, M

KRUGER, G

VERRON, G

机构：

[1] UNIV ROSTOCK, CHILDRENS HOSP, DIV NEONATOL & CLIN GENET, O-2500 ROSTOCK, GERMANY

[2] INST MARINE SCI, ROSTOCK, GERMANY

[3] MED ACAD CARL GUSTAV CARUS, DEPT CLIN GENET, DRESDEN, GERMANY

[4] UNIV JENA, CHILDRENS HOSP, O-6900 JENA, GERMANY

[5] MARTIN LUTHER UNIV, CHILDRENS HOSP, O-4010 HALLE, GERMANY

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1991年 / 40卷 / 04期

关键词：

DISORDER-SPECIFIC GROWTH CURVE; PUBERTAL GROWTH SPURT; SAGER; 2-COMPONENTS-CONCEPT;

D O I：

10.1002/ajmg.1320400404

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

By means of an appropriate mathematical model (Sager's 2-components-concept) a delayed spontaneous pubertal growth spurt can be demonstrated in girls with 45,X Ullrich-Turner syndrome (UTS) (n1 = 45) as well as in those with 45,X/46,XX mosaicism (n2 = 14) never treated with any growth stimulating drug. On the average, this growth spurt begins later and its extent is smaller (mean growth rate = 3.10 and 2.79 cm, respectively, in the 15th year of chronological age) than in normal girls. The delay in acute growth spurt corresponds very well to the delay of skeletal maturation in the UTS (on the average 2 to 3 years of chronological age).

引用

页码：401 / 405

页数：5

共 29 条

[1] NEW ASPECTS OF ESTROGEN GESTAGEN-INDUCED GROWTH AND ENDOCRINE CHANGES IN INDIVIDUALS WITH TURNER SYNDROME [J].