CELL-SPECIFIC EXPRESSION OF AROMATASE AND LH RECEPTOR MESSENGER-RNAS IN RAT OVARY

被引：58

作者：

WHITELAW, PF ^{[1
]}

SMYTH, CD ^{[1
]}

HOWLES, CM ^{[1
]}

HILLIER, SG ^{[1
]}

机构：

[1] SERONO LABS LTD,WELWYN GARDEN CIT AL7 1BG,HERTS,ENGLAND

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 1992年 / 9卷 / 03期

关键词：

D O I：

10.1677/jme.0.0090309

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Current understanding of the endocrine and paracrine regulation of follicular oestrogen synthesis predicts that aromatase cytochrome P450 (P450arom) mRNA is inducible by FSH in granulosa cells. LH receptor mRNA is constitutively expressed in thecal/interstital cells, and is also thought to be induced in granulosa cells in response to joint stimulation by FSH and oestrogen. This study provides direct evidence that FSH induces the ovarian P450arom gene selectively, perhaps exclusively,in the granulosa cells of Graafian follicles. FSH-induction of LH receptor mRNA occurs simultaneously but is independent of oestrogen synthesis per se.

引用

页码：309 / 312

页数：4

共 17 条

[1]

ARMSTRONG DT, 1979, REGULATORY MECHANISM, V2, P217

[2] IMMUNOCYTOCHEMICAL LOCALIZATION AND ENZYMATIC DISTRIBUTION OF RAT OVARIAN AROMATASE [J].

ELMAASARANY, S ;

BRANDT, ME ;

MAJERCIK, MH ;

ZIMNISKI, SJ ;

PUETT, D .

BIOLOGY OF REPRODUCTION, 1991, 44 (03) :550-560

[3] LUTEINIZING-HORMONE RECEPTOR INDUCTION IN DISPERSED GRANULOSA-CELLS REQUIRES ESTROGEN [J].

FAROOKHI, R ;

DESJARDINS, J .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1986, 47 (1-2) :13-24

[4] AROMATASE CYTOCHROME-P450 IN RAT OVARIAN GRANULOSA-CELLS BEFORE AND AFTER LUTEINIZATION - ADENOSINE 3',5'-MONOPHOSPHATE-DEPENDENT AND INDEPENDENT REGULATION - CLONING AND SEQUENCING OF RAT AROMATASE CDNA AND 5' GENOMIC DNA [J].

HICKEY, GJ ;

KRASNOW, JS ;

BEATTIE, WG ;

RICHARDS, JS .

MOLECULAR ENDOCRINOLOGY, 1990, 4 (01) :3-12

[5] CONTROL OF PREOVULATORY FOLLICULAR ESTROGEN BIOSYNTHESIS IN THE HUMAN-OVARY [J].

HILLIER, SG ;

REICHERT, LE ;

VANHALL, EV .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1981, 52 (05) :847-856

[6]

HILLIER SG, 1985, OXFORD REV REPROD B, V7, P168

[7] HORMONAL-REGULATION OF THE DIFFERENTIATION OF CULTURED OVARIAN GRANULOSA-CELLS [J].

HSUEH, AJW ;

ADASHI, EY ;

JONES, PBC ;

WELSH, TH .

ENDOCRINE REVIEWS, 1984, 5 (01) :76-127

[8] EXPRESSION OF AROMATASE CYTOCHROME-P-450 IN PREMENOPAUSAL AND POSTMENOPAUSAL HUMAN OVARIES - AN IMMUNOCYTOCHEMICAL STUDY [J].

INKSTER, SE ;

BRODIE, AMH .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 73 (04) :717-726

[9] GONADOTROPIN-INDUCED UP-REGULATION AND DOWN-REGULATION OF RAT OVARIAN LH RECEPTOR MESSAGE LEVELS DURING FOLLICULAR-GROWTH, OVULATION AND LUTEINIZATION [J].

LAPOLT, PS ;

OIKAWA, M ;

JIA, XC ;

DARGAN, C ;

HSUEH, AJW .

ENDOCRINOLOGY, 1990, 126 (06) :3277-3279

[10]

MCFARLAND KC, 1989, SCIENCE, V245, P495

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