INHIBITION OF NITRIC-OXIDE (NO) PRODUCTION SELECTIVELY IMPAIRS LEARNING AND MEMORY IN THE RAT

被引：88

作者：

ESTALL, LB ^{[1
]}

GRANT, SJ ^{[1
]}

CICALA, GA ^{[1
]}

机构：

[1] UNIV DELAWARE, PROGRAM NEUROSCI, NEWARK, DE 19716 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 46卷 / 04期

关键词：

NITRIC OXIDE; N-W-NITRO-L-ARGININE METHYL ESTER; N-METHYL-D-ASPARTATE (NMDA); LEARNING AND MEMORY; RAT; BEHAVIOR;

D O I：

10.1016/0091-3057(93)90228-L

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Animals administered the nitric oxide (NO) synthase inhibitor N-w-nitro-L-arginine methyl ester (NAME) for five days exhibited severe deficits in acquisition of a place-navigation learning task. The effect of NAME was selective to place-navigation learning. NAME had no effect on sensorimotor or motivational processes in a related task. These results are consistent with the view that NO participates in learning and execution of memory tasks.

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页码：959 / 962

页数：4

相关论文

共 14 条

[1] POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN LONG-TERM POTENTIATION [J].

BOHME, GA ;

BON, C ;

STUTZMANN, JM ;

DOBLE, A ;

BLANCHARD, JC .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 199 (03) :379-381

[2]

COLLINGRIDGE GL, 1989, PHARMACOL REV, V41, P143

[3] THE ANTAGONISM OF AMINO ACID-INDUCED EXCITATIONS OF RAT HIPPOCAMPAL CA1 NEURONS INVITRO [J].

COLLINGRIDGE, GL ;

KEHL, SJ ;

MCLENNAN, H .

JOURNAL OF PHYSIOLOGY-LONDON, 1983, 334 (JAN) :19-31

[4] NITRIC-OXIDE SYNTHASE - IRREVERSIBLE INHIBITION BY L-NG-NITROARGININE IN BRAIN INVITRO AND INVIVO [J].

DWYER, MA ;

BREDT, DS ;

SNYDER, SH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 176 (03) :1136-1141

[5] ENDOTHELIUM-DERIVED RELAXING FACTOR RELEASE ON ACTIVATION OF NMDA RECEPTORS SUGGESTS ROLE AS INTERCELLULAR MESSENGER IN THE BRAIN [J].

GARTHWAITE, J ;

CHARLES, SL ;

CHESSWILLIAMS, R .

NATURE, 1988, 336 (6197) :385-388

[6] NMDA RECEPTOR ACTIVATION INDUCES NITRIC-OXIDE SYNTHESIS FROM ARGININE IN RAT-BRAIN SLICES [J].

GARTHWAITE, J ;

GARTHWAITE, G ;

PALMER, RMJ ;

MONCADA, S .

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1989, 172 (4-5) :413-416

[7] LONG-TERM POTENTIATION IN THE HIPPOCAMPUS INVOLVES ACTIVATION OF N-METHYL-D-ASPARTATE RECEPTORS [J].

HARRIS, EW ;

GANONG, AH ;

COTMAN, CW .

BRAIN RESEARCH, 1984, 323 (01) :132-137

[8]

MONDADORI C, 1989, EXP BRAIN RES, V75, P449

[9] DEVELOPMENTS OF A WATER-MAZE PROCEDURE FOR STUDYING SPATIAL-LEARNING IN THE RAT [J].

MORRIS, R .

JOURNAL OF NEUROSCIENCE METHODS, 1984, 11 (01) :47-60

[10] SELECTIVE IMPAIRMENT OF LEARNING AND BLOCKADE OF LONG-TERM POTENTIATION BY AN N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST, AP5 [J].

MORRIS, RGM ;

ANDERSON, E ;

LYNCH, GS ;

BAUDRY, M .

NATURE, 1986, 319 (6056) :774-776