PRACTICAL, LARGE-SCALE SYNTHESIS OF 2,2-DIMETHYL-5-HYDROXY-4-OXO-BENZO-1,4-DIOXIN

被引：52

作者：

HADFIELD, A ^{[1
]}

SCHWEITZER, H ^{[1
]}

TROVA, MP ^{[1
]}

GREEN, K ^{[1
]}

机构：

[1] AMER CYANAMID CO,DEPT CHEM ORGAN & IMMUNOL,PEARL RIVER,NY 10965

来源：

SYNTHETIC COMMUNICATIONS | 1994年 / 24卷 / 07期

关键词：

Dihydroxybenzoic acids - Large scale synthesis - Thionyl chlorides - Title compounds;

D O I：

10.1080/00397919408020778

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Modification of a known procedure employing the interaction of thionyl chloride, acetone, and 2,6-dihydroxybenzoic acid was found, to provide the title compound in multikilogram quantities of acceptable yield and purity.

引用

页码：1025 / 1028

页数：4

共 5 条

[1]

ALRAWI JMA, 1981, IRAQI J SCI, V22, P300

[2]

BONSIGNORE L, 1978, REND SEM FAC SCI, V48, P275

[3] TOTAL SYNTHESES OF KS-501, KS-502, AND THEIR ENANTIOMERS [J].

DUSHIN, RG ;

DANISHEFSKY, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (02) :655-659

[4] THE REACTION BETWEEN KETONES AND THIONYL CHLORIDE [J].

PIZEY, JS ;

SYMEONIDES, K .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1980, 8 (01) :1-8

[5] ANALOGS OF PLATELET-ACTIVATING-FACTOR .6. MONO-ARYL AND BIS-ARYL PHOSPHATE ANTAGONISTS OF PLATELET-ACTIVATING-FACTOR [J].

WISSNER, A ;

CARROLL, ML ;

GREEN, KE ;

KERWAR, SS ;

PICKETT, WC ;

SCHAUB, RE ;

TORLEY, LW ;

WRENN, S ;

KOHLER, CA .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (09) :1650-1662

← 1 →