SYNTHESIS AND BIOASSAY OF CARBAMATE INHIBITORS OF THE JUVENILE-HORMONE HYDROLYZING ESTERASES FROM THE HOUSEFLY, MUSCA-DOMESTICA

Twenty N-alkyl carbamate derivatives of geranyl phenyl ethers were synthesized and tested for juvenile hormone and anti-juvenile hormone activity against Oncopeltus fasciatus, Lygus lineolaris, Trichoplusiani, Tenebrio molitor, Culex pipens quinquefasciatus, and Musca domestica. Low juvenile hormone-like activity was found ononly the Diptera. The compounds were also assayed as inhibitors of the esterases which hydrolyze juvenile hormone in Blaberus giganteus, T. ni, and M. domestica. Negligible inhibition of B. giganteus and T. ni esterases was found, but the meta-substituted carbamates proved to be very potent inhibitors of M. domestica juvenile hormone esterases, as were some N-alkyl carbamates of 1-naphthol. © 1979, American Chemical Society. All rights reserved.