INTERACTION OF AGING WITH INVITRO ADRENOCORTICAL RESPONSIVENESS TO ACTH AND CYCLIC-AMP

被引：19

作者：

PRITCHETT, JF ^{[1
]}

SARTIN, JL ^{[1
]}

MARPLE, DN ^{[1
]}

HARPER, WL ^{[1
]}

TILL, ML ^{[1
]}

机构：

[1] AUBURN UNIV,AGR EXPT STN,DEPT ANIM SCI,AUBURN,AL 36830

来源：

HORMONE RESEARCH | 1979年 / 10卷 / 2-3期

关键词：

Corticosterone; Corticotrophin; Cyclic nucleotide; Maturation;

D O I：

10.1159/000178993

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In vitro adrenal accumulation of cyclic 3'5’-adenosine monophosphate (cyclic AMP) and release of corticosterone in response to adrenocorticotropic hormone (ACTH), cyclic AMP or theophylline was assessed in 60- and 340-day-old male rats. Adrenal tissue from mature animals secreted significantly smaller quantities of corticosterone in response to ACTH, theophylline or cyclic AMP. Additionally, mature tissue accumulated significantly less cyclic AMP after treatment with ACTH or a combination of ACTH and theophylline. The data suggest an age-related refractoriness of adrenal cortical tissue to ACTH which may in part be related to decreased availability of and/or sensitivity to cyclic AMP. © 1979 S. Karger AG, Basel.

引用

页码：96 / 103

页数：8

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