MOLECULAR CHARACTERIZATION OF ALPHA-1-ADRENOCEPTORS AND ALPHA-2-ADRENOCEPTORS

被引：171

作者：

HARRISON, JK ^{[1
]}

PEARSON, WR ^{[1
]}

LYNCH, KR ^{[1
]}

机构：

[1] UNIV VIRGINIA,SCH MED,DEPT BIOCHEM,CHARLOTTESVILLE,VA 22908

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1991年 / 12卷 / 02期

关键词：

D O I：

10.1016/0165-6147(91)90499-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Three 'alpha-1-adrenoceptors' and three 'alpha-2-adrenoceptors' have now been cloned. How closely do these receptors match the native receptors that have been identified pharmacologically? What are the properties of these receptors, and how do they relate to other members of the cationic amine receptor family? Kevin Lynch and his colleagues discuss these questions in this review.

引用

页码：62 / 67

页数：6

共 31 条

[1] A STUDY OF THE ADRENOTROPIC RECEPTORS
AHLQUIST, RP
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1948, 153 (03): : 586 - 600
[2] FUNCTIONAL BASIS FOR CLASSIFICATION OF ALPHA-ADRENERGIC RECEPTORS
BERTHELSEN, S
PETTINGER, WA
[J]. LIFE SCIENCES, 1977, 21 (05) : 595 - 606
[3] SUBTYPES OF ALPHA-2-ADRENOCEPTORS - PHARMACOLOGICAL AND MOLECULAR BIOLOGICAL EVIDENCE CONVERGE
BYLUND, DB
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (10) : 356 - 361
[4] BYLUND DB, 1988, J PHARMACOL EXP THER, V245, P660
[5] CHALBERG SC, 1990, MOL CELL BIOCHEM, V97, P161
[6] CLARK RB, 1989, MOL PHARMACOL, V36, P343
[7] MOLECULAR-CLONING AND EXPRESSION OF THE CDNA FOR THE HAMSTER ALPHA-1-ADRENERGIC RECEPTOR
COTECCHIA, S
SCHWINN, DA
RANDALL, RR
LEFKOWITZ, RJ
CARON, MG
KOBILKA, BK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (19) : 7159 - 7163
[8] COTECCHIA S, 1990, J BIOL CHEM, V265, P63
[9] CLONING OF THE GENE AND CDNA FOR MAMMALIAN BETA-ADRENERGIC-RECEPTOR AND HOMOLOGY WITH RHODOPSIN
DIXON, RAF
KOBILKA, BK
STRADER, DJ
BENOVIC, JL
DOHLMAN, HG
FRIELLE, T
BOLANOWSKI, MA
BENNETT, CD
RANDS, E
DIEHL, RE
MUMFORD, RA
SLATER, EE
SIGAL, IS
CARON, MG
LEFKOWITZ, RJ
STRADER, CD
[J]. NATURE, 1986, 321 (6065) : 75 - 79
[10] STRUCTURAL FEATURES REQUIRED FOR LIGAND-BINDING TO THE BETA-ADRENERGIC-RECEPTOR
DIXON, RAF
SIGAL, IS
CANDELORE, MR
REGISTER, RB
SCATTERGOOD, W
RANDS, E
STRADER, CD
[J]. EMBO JOURNAL, 1987, 6 (11) : 3269 - 3275

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