THE HIGH-AFFINITY RECEPTOR FOR OMEGA-CONOTOXIN REPRESENTS CALCIUM CHANNELS DIFFERENT FROM THOSE SENSITIVE TO DIHYDROPYRIDINES IN MAMMALIAN BRAIN

A monoclonal antibody recognizing the α2δ complex of the dihydropyridine (DHP)-sensitive calcium channel of skeletal muscle immunoprecipitated most of the DHP receptor solubilized from bovine and rabbit brains, and bovine cardiac muscle. However, it did not significantly immunoprecipitate the high affinity ω-conotoxin receptor solubilized from these brains. These results indicate that the DHP receptor and the high affinity ω-conotoxin receptor are different molecules in mammalian brain. © 1990 Academic Press, Inc.