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PH REGULATION OF PENICILLIN PRODUCTION IN ASPERGILLUS-NIDULANS

被引：43
作者：
SHAH, AJ
TILBURN, J
ADLARD, MW
ARST, HN
机构：
[1] ROYAL POSTGRAD MED SCH,DEPT BACTERIOL,DUCANE RD,LONDON W12 0NN,ENGLAND
[2] POLYTECH CENT LONDON,SCH BIOL & HLTH SCI,LONDON W1M 8JS,ENGLAND
来源：
FEMS MICROBIOLOGY LETTERS | 1991年 / 77卷 / 2-3期
关键词：
ASPERGILLUS-NIDULANS; PENICILLIN; PH REGULATION; MUTATION;
D O I：
10.1111/j.1574-6968.1991.tb04349.x
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
As shown by both bioassay and high-performance liquid chromatographic (HPLC) analysis, penicillin G production by Aspergillus nidulans is subject to regulation by the pH of the growth medium. Penicillin titres were highest at alkaline pH and in strains carrying mutations in the regulatory gene pacC which mimics the effects of growth at alkaline pH. They were lowest at acid pH and in strains carrying mutations in the palA, palB, palC, palE or palF genes which mimic the effects of growth at acid pH.
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页码：209 / 212
页数：4
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