THE NUCLEAR PROTOONCOGENES C-JUN AND C-FOS AS REGULATORS OF DNA-REPLICATION

被引：98

作者：

MURAKAMI, Y

SATAKE, M

YAMAGUCHIIWAI, Y

SAKAI, M

MURAMATSU, M

ITO, Y

机构：

[1] KYOTO UNIV,INST VIRUS RES,DEPT VIRAL ONCOL,SHOGOIN,SAKYO KU,KYOTO 606,JAPAN

[2] HOKKAIDO UNIV,SCH MED,DEPT BIOCHEM,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

[3] UNIV TOKYO,FAC MED,DEPT BIOCHEM,BUNKYO KU,TOKYO 113,JAPAN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 09期

关键词：

POLYOMAVIRUS; TRANSCRIPTION FACTORS AP1 AND CREB; ENHANCER;

D O I：

10.1073/pnas.88.9.3947

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Polyomavirus (Py) DNA replication is regulated by its enhancer, which contains an AP1 site. c-Jun and c-Fos, the products of nuclear protooncogenes c-jun and c-fos, form the heterodimeric transcriptional activating factor AP1. Overexpression of c-fos and c-jun genes strongly stimulated Py DNA replication from the Py origin of replication as well as transcription from the Py early promoter through the AP1 binding site. The cAMP response element (CRE)-binding protein CREB stimulated only transcription, not DNA replication, through the CRE under similar conditions. The results indicate that AP1 functions as a regulator of DNA replication and that the mechanism of activation of Py DNA replication by AP1 is distinct from that of activation of transcription from the Py early promoter.

引用

页码：3947 / 3951

页数：5

共 47 条

[1] A POLYOMAVIRUS ENHANCER-BINDING PROTEIN, PEBP5, RESPONSIVE TO 12-O-TETRADECANOYLPHORBOL-13-ACETATE BUT DISTINCT FROM AP-1 [J].