CISPLATIN-INDUCED IMBALANCES IN THE PATTERN OF CHIMERIC MARKER GENE-EXPRESSION IN HELA-CELLS

被引：14

作者：

EVANS, GL ^{[1
]}

GRALLA, JD ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91149-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The effects of the antitumor drug cisplatin on gene expression have been measured during transient transfections in HeLa cells. The results indicate a surprising diversity of response. Expression from two promoters is strongly induced, both in non-replicating plasmids and cellular integrants, whereas expression from two other promoters is strongly inhibited. The results suggest that a drug-induced imbalance in gene expression may contribute to the antitumor properties of cisplatin. © 1992.

引用

页码：1 / 8

页数：8

共 31 条

[1]

ACTIVATION OF PROGRAMMED CELL-DEATH (APOPTOSIS) BY CISPLATIN, OTHER ANTICANCER DRUGS, TOXINS AND HYPERTHERMIA [J].

BARRY, MA ;

BEHNKE, CA ;

EASTMAN, A .

BIOCHEMICAL PHARMACOLOGY, 1990, 40 (10) :2353-2362

[2]

THE MOLECULAR-GENETICS OF CANCER [J].

BISHOP, JM .

SCIENCE, 1987, 235 (4786) :305-311

[3]

CISPLATIN RESISTANCE AND MECHANISM IN A VIRAL TEST SYSTEM - SV40 ISOLATES THAT RESIST INHIBITION BY THE ANTITUMOR DRUG HAVE LOST REGULATORY DNA [J].

BUCHANAN, RL ;

GRALLA, JD .

BIOCHEMISTRY, 1990, 29 (14) :3436-3442

[4]

CHU G, 1987, MOL BIOL MED, V4, P277

[5]

CLONE, UNPUB IMPERIAL CANCE

[6]

CHARACTERIZATION OF THE REACTIONS OF PLATINUM ANTITUMOR AGENTS WITH BIOLOGIC AND NONBIOLOGICAL SULFUR-CONTAINING NUCLEOPHILES [J].

DEDON, PC ;

BORCH, RF .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (12) :1955-1964

[7]

UPSTREAM REGULATORY REGIONS REQUIRED TO STABILIZE BINDING TO THE TATA SEQUENCE IN AN ADENOVIRUS EARLY PROMOTER [J].

GARCIA, J ;

WU, F ;

GAYNOR, R .

NUCLEIC ACIDS RESEARCH, 1987, 15 (20) :8367-8385

[8]

RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS [J].

GORMAN, CM ;

MOFFAT, LF ;

HOWARD, BH .

MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (09) :1044-1051

[9]

GRALLA JD, 1987, CANCER RES, V47, P5092

[10]

GENETIC CHANGES IN MAMMALIAN-CELLS REMINISCENT OF AN SOS RESPONSE [J].

HERRLICH, P ;

MALLICK, U ;

PONTA, H ;

RAHMSDORF, HJ .

HUMAN GENETICS, 1984, 67 (04) :360-368

← 1 2 3 4 →