INCORPORATION OF N-ACYL-2-AMINO-2-DEOXY-HEXOSES INTO GLYCOSPHINGOLIPIDS OF THE PHEOCHROMOCYTOMA CELL-LINE PC-12

被引：39

作者：

KAYSER, H ^{[1
]}

GEILEN, CC ^{[1
]}

PAUL, C ^{[1
]}

ZEITLER, R ^{[1
]}

REUTTER, W ^{[1
]}

机构：

[1] FREE UNIV BERLIN, INST MOLEK BIOL & BIOCHEM, ARNIMALLEE 22, W-1000 BERLIN 33, GERMANY

来源：

FEBS LETTERS | 1992年 / 301卷 / 02期

关键词：

N-ACYL NEURAMINIC ACID BIOSYNTHESIS; SYNTHESIS OF RADIOLABELED N-ACYL-2-AMINO-2-DEOXY-HEXOSE; GLYCOSPHINGOLIPID; PC-12; CELL;

D O I：

10.1016/0014-5793(92)81233-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of N-acyl-2-amino-2-deoxy-hexoses, their metabolism and their incorporation into glycosphingolipids of rat pheochromocytoma cell line PC 12 were investigated. The data indicate that in PC 12 cells the N-acyl-2-amino-2-deoxy-hexoses, N-propanoyl-D-glucosamine and N-butanoyl-D-glucosamine are metabolized to the corresponding phosphates, and that N-propanoyl-D-glucosamine is also metabolized to N-propanoyl neuraminic acid. Using variously radiolabelled N-acyl-2-amino-2-deoxy-hexoses, their incorporation into glycosphingolipids was shown.

引用

页码：137 / 140

页数：4

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