TNF ALPHA-INDUCED EXPRESSION OF ENDOTHELIAL ADHESION MOLECULES, ICAM-1 AND VCAM-1, IS LINKED TO PROTEIN-KINASE-C ACTIVATION

被引：90

作者：

MATTILA, P ^{[1
]}

MAJURI, ML ^{[1
]}

MATTILA, PS ^{[1
]}

RENKONEN, R ^{[1
]}

机构：

[1] UNIV HELSINKI,DEPT BACTERIOL,HAARTMANINKATU 3,SF-00290 HELSINKI 29,FINLAND

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1992年 / 36卷 / 02期

关键词：

D O I：

10.1111/j.1365-3083.1992.tb03087.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of protein kinase C (PKC) in TNF-alpha-induced activation of endothelial adhesion molecules ICAM-1 and VCAM-1 was analysed. Phorbol myristate acetate, which is known to activate PKC, was able to mimic TNF-alpha-induced up-regulation of ICAM-1 and partly also VCAM-1 expression. Similarly a PKC inhibitor, H7, but not another kinase inhibitor, HA1004, inhibited TNF-alpha-induced enhancement of ICAM-1 expression at both the mRNA and the protein level. Moreover we were able to measure a transient PKC activation peak at 16 min after TNF-alpha-induction in endothelial cells analysed by phorbol-dibutyrate binding. These results indicate that the TNF-alpha-induced effect on the regulation of endothelial adhesion molecule expression is at least partly mediated by PKC activation.

引用

页码：159 / 165

页数：7

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