DESMIN AND VIMENTIN AS MARKERS OF REGENERATION IN MUSCLE DISEASES

被引：71

作者：

GALLANTI, A

PRELLE, A

MOGGIO, M

CISCATO, P

CHECCARELLI, N

SCIACCO, M

COMINI, A

SCARLATO, G

机构：

[1] Istituto di Clinica Neurologica, Centro 'Dino Ferrari', Università degli Studi, Milano, I-20122, Via F. Sforza

来源：

ACTA NEUROPATHOLOGICA | 1992年 / 85卷 / 01期

关键词：

IMMUNOHISTOCHEMISTRY; VIMENTIN; DESMIN; MUSCLE; REGENERATION;

D O I：

10.1007/BF00304637

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Localization and distribution of desmin and vimentin have been studied in different neuromuscular disorders using monoclonal antibodies. We have demonstrated that vimentin, although virtually absent in normal human muscle fibers, is expressed in regenerating fibers in different neuromuscular disorders. Moreover, these fibers showed a strong positivity with desmin antibodies. In normal muscle fibers desmin is only localized at Z-line level. These results suggest that desmin and vimentin may be over-expressed during muscle regeneration processes, probably because of their importance in the structural organization of the sarcomere.

引用

页码：88 / 92

页数：5

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