A CONVENIENT PROCEDURE FOR THE SYNTHESIS OF BIS-STEROIDAL PYRAZINES - MODELS FOR THE CEPHALOSTATINS

被引：52

作者：

SMITH, SC ^{[1
]}

HEATHCOCK, CH ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 24期

关键词：

D O I：

10.1021/jo00050a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient routes have been developed for both symmetrical and unsymmetrical bis-steroidal pyrazines from readily available precursors.

引用

页码：6379 / 6380

页数：2

共 14 条

[1] SPECTRAL AND CHEMICAL-PROPERTIES OF DIMETHYLDIOXIRANE AS DETERMINED BY EXPERIMENT AND ABINITIO CALCULATIONS [J].

ADAM, W ;

CHAN, YY ;

CREMER, D ;

GAUSS, J ;

SCHEUTZOW, D ;

SCHINDLER, M .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (13) :2800-2803

[2] DIOXIRANES - A NEW CLASS OF POWERFUL OXIDANTS [J].

ADAM, W ;

CURCI, R ;

EDWARDS, JO .

ACCOUNTS OF CHEMICAL RESEARCH, 1989, 22 (06) :205-211

[3] BROMINATIONS WITH PYRIDINE HYDROBROMIDE PERBROMIDE [J].

DJERASSI, C ;

SCHOLZ, CR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1948, 70 (01) :417-418

[4] PERCHLORIC ACID CATALYZED ACYLATIONS . ENOL LACTONIZATION AND ENOL ACETYLATION OF STEROIDS [J].

EDWARDS, BE ;

RAO, PN .

JOURNAL OF ORGANIC CHEMISTRY, 1966, 31 (01) :324-&

[5] DIOXIRANES - SYNTHESIS AND REACTIONS OF METHYLDIOXIRANES [J].

MURRAY, RW ;

JEYARAMAN, R .

JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (16) :2847-2853

[6] CHEMISTRY OF DIOXIRANES .12. DIOXIRANES [J].

MURRAY, RW .

CHEMICAL REVIEWS, 1989, 89 (05) :1187-1201

[7]

OHTA G, 1968, CHEM PHARM BULL, V16, P1497

[8] ISOLATION AND STRUCTURE OF THE HEMICHORDATE CELL-GROWTH INHIBITORS CEPHALOSTATIN-2, CEPHALOSTATIN-3, AND CEPHALOSTATIN-4 [J].

PETTIT, GR ;

INOUE, M ;

KAMANO, Y ;

DUFRESNE, C ;

CHRISTIE, N ;

NIVEN, ML ;

HERALD, DL .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1988, (13) :865-867

[9] ANTINEOPLASTIC AGENTS .214. ISOLATION AND STRUCTURE OF CEPHALOSTATINS 7-9 [J].

PETTIT, GR ;

KAMANO, Y ;

INOUE, M ;

DUFRESNE, C ;

BOYD, MR ;

HERALD, CL ;

SCHMIDT, JM ;

DOUBEK, DL ;

CHRISTIE, ND .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (02) :429-431

[10] ISOLATION AND STRUCTURE OF THE UNUSUAL INDIAN-OCEAN CEPHALODISCUS-GILCHRISTI COMPONENTS, CEPHALOSTATINS 5 AND 6 [J].

PETTIT, GR ;

KAMANO, Y ;

DUFRESNE, C ;

INOUE, M ;

CHRISTIE, N ;

SCHMIDT, JM ;

DOUBEK, DL .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1989, 67 (10) :1509-1513

← 1 2 →