THE PRESENCE OF LYSYLPYRIDINOLINE IN THE HYPERTROPHIC CARTILAGE OF NEWLY-HATCHED CHICKS

被引：9

作者：

ORTH, MW

MARTINEZ, DA

COOK, ME

VAILAS, AC

机构：

[1] UNIV WISCONSIN,DEPT NUTR,MADISON,WI 53706

[2] UNIV WISCONSIN,DEPT POULTRY SCI,MADISON,WI 53706

[3] UNIV WISCONSIN,BIODYNAM LAB,MADISON,WI 53706

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1157卷 / 03期

基金：

美国国家航空航天局;

关键词：

HYPERTROPHIC CARTILAGE; TIBIAL DYSCHONDROPLASIA; COLLAGEN; CROSS-LINKING; (CHICKEN);

D O I：

10.1016/0304-4165(93)90104-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of lysylpyridinoline (LP) as a nonreducible cross-link in appreciable quantities has primarily been limited to the mineralized tissues, bone and dentin. However, the results reported here show that LP is not only present in the hypertrophic cartilage of the tibiotarsus isolated from newly hatched broiler chicks, but it is approx. 4-fold as concentrated as hydroxylysylpyridinoline (HP). Bone and articular cartilage surrounding the hypertrophic cartilage do not contain measurable quantities of LP. Purified LP has a flourescent scan similar to purified HP and literature values, confirming that we indeed were measuring LP. Also, the cartilage lesion produced by immature chondrocytes from birds with tibial dyschondroplasia had LP but the HP: LP ratio was > 1. Thus, the low HP:LP ratio could be a marker for hypertrophic cartilage in avians.

引用

页码：229 / 232

页数：4

共 18 条

[1]

ARQUHARSON C, 1989, P SOC EXP BIOL MED, V192, P166

[2]

BASHEY RI, 1989, LAB INVEST, V60, P106

[3] TYPE-X COLLAGEN - COVALENT CROSS-LINKING TO HYPERTROPHIC CARTILAGE-COLLAGEN FIBRILS [J].