SELECTIVE REVERSAL OF VINBLASTINE RESISTANCE IN MULTIDRUG-RESISTANT CELL-LINES BY TAMOXIFEN, TOREMIFENE AND THEIR METABOLITES

被引：36

作者：

KIRK, J

HOULBROOK, S

STUART, NSA

STRATFORD, IJ

HARRIS, AL

CARMICHAEL, J

机构：

[1] MRC,RADIOTHERAPY UNIT,CHILTON OX11 0RD,ENGLAND

[2] CHURCHILL HOSP,ICRF,CLIN ONCOL UNIT,OXFORD OX3 7LJ,ENGLAND

来源：

EUROPEAN JOURNAL OF CANCER | 1993年 / 29A卷 / 08期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0959-8049(05)80306-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study we describe the effects of tamoxifen, toremifene and their 4-hydroxy and N-desmethyl metabolites on the toxicity of a range of drugs to human breast and lung cancer and to Chinese hamster ovary cell lines, determined using a tetrazolium-based semi-automated colorimetric assay. Vinblastine resistance was completely abolished in an mdr1-transfected lung cancer cell line (S1/1.1), indicating that P-glycoprotein-mediated multidrug resistance can be fully reversed by anti-oestrogens. A substantial (14- to 39-fold) enhancement of vinblastine toxicity to highly multidrug-resistant (MCF-7Adr) cells expressing P-glycoprotein was also observed in the presence of tamoxifen, toremifene and their metabolites, while m-amsacrine, cisplatin and melphalan toxicity was unaffected.

引用

页码：1152 / 1157

页数：6

共 29 条

[1]

BAAS F, 1990, CANCER RES, V50, P5392

[2]

BATIST G, 1986, J BIOL CHEM, V261, P1554

[3]

BENSON AB, 1985, CANCER TREAT REP, V69, P795

[4] BREAST TUMOR-CELL LINES FROM PLEURAL EFFUSIONS [J].